Bolus Injection in Hypertensive Patients
نویسندگان
چکیده
A 10 mg bolus of the angiotensin blocker saralasin was injected 113 times in 68 subjects with essential or renovascular hypertension. Ninety percent of injections caused a transient increase in blood pressure, which correlated with plasma renin activity (PRA) (r = -0.54). Mean increase at 2 minutes was 21/13.4 mm Hg (P < 0.001) and was independent of pre-injection control blood pressure, with a rapid decrease to or below control values thereafter. Thirty-seven subjects were studied on successive days before and after furosemide-induced sodium depletion (152 ± 26 mEq [SE]
منابع مشابه
Pressor response to saralasin (1-sar-8-ala-angiotensin II) bolus injection in hypertensive patients.
A 10 mg bolus of the angiotensin blocker saralasin was injected 113 times in 68 subjects with essential or renovascular hypertension. Ninety percent of injections caused a transient increase in blood pressure, which correlated with plasma renin activity (PRA) (r = -0.54); Mean increase at 2 minutes was 21/13.4 mm Hg (P less than 0.001) and was independent of pre-injection control blood pressure...
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تاریخ انتشار 2005